Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1.
نویسندگان
چکیده
We investigated the activation of transient receptor potential cation channel (TRP) subfamily V, member 1 (TRPV1) and TRP subfamily A, member 1 (TRPA1) by 1'-acetoxychavicol acetate (ACA), the main pungent component in galangal. ACA did not activate TRPV1-expressing human embryonic kidney (HEK) cells, but strongly activated TRPA1-expressing HEK cells. ACA was more potent than allyl isothiocyanate, the typical TRPA1 agonist.
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عنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 74 8 شماره
صفحات -
تاریخ انتشار 2010